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Reducing Calorie Intake May Not Help You Lose Weight

We often try to lose weight by eating a diet that’s low in calories. The diet helps in losing those extra kilos, but according to a recent study, it may not help individuals with difficult-to-treat obesity lose weight – and keep it off. The study emphasized the need for exercise among such people.Also Read – Obesity: 5 Mental Health Issues That Impact Your Body Weight

Understanding distinct obesity phenotypes are key to teasing out insights into individual variations in weight loss. Also Read – Struggling With Belly Fat? Lose Weight By Managing This One Hormone

And for “diet-resistant” obesity — patients in the bottom 20 percent for the rate of weight loss following a low-calorie diet — exercise training should be prioritized, as it decreases fat mass and boosts skeletal muscle metabolism, according to the new research published in the journal ebiomedicine. Also Read – Weight Loss Ayurvedic Powder: 1 Magical Ayurvedic Mixture to Help You Reduce Kilos

“For those individuals who have obesity and who’ve had enormous difficulty losing weight, the message for them is: You are in a group of individuals for whom exercise is particularly important. And that’s really going to help you lose weight,” said Dr. Ruth McPherson, Professor at the University of Ottawa’s Faculty of Medicine.

For the study, the research team mined clinical data from over 5,000 records. Ultimately, 228 files were reviewed and a subset of 20 women with obesity was identified to undergo a closely supervised exercise program made up of 18 progressive sessions using treadmills and weights done three times per week for six weeks.

Using bioinformatics and machine learning approaches to analyze skeletal muscle, the results indicate that exercise preferentially improves skeletal muscle metabolism and enhances weight loss capacity for individuals with obesity who are deemed diet resistant.

These are the type of patients with difficult-to-treat obesity who have often been accused of non-adherence when they have not lost weight with diet restriction.

The stakes are high: The number of people who are overweight or obese has grown to epidemic proportions globally and obesity is a risk factor in a slew of chronic diseases.

“If you look at a large group of people who are overweight and trying to lose weight, they don’t respond to exercise very much. But now we’ve found that people in this (diet-resistant) obesity phenotype really do, said Dr Robert Dent, an endocrinologist at the university.

“What the findings are telling us is that when we see individuals with obesity who don’t respond to dietary restriction, they should be shunted over to physical activity.”

The study has the potential to help reshape the science of weight-loss programs so they can be customized for individual patients.


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